Isotopically Labeled Compounds
Medchemexpress LLC Pacritinib-d4 | 476.60 | 5 MG
Pacritinib-d4 (SB1518-d4) is the deuterium labeled Pacritinib. It is a potent inhibitor of both wild-type JAK2 (IC50=23 nM) and JAK2V617F mutant (IC50=19 nM). This compound also inhibits FLT3 (IC50=22 nM) and its mutant FLT3D835Y (IC50=6 nM). Stable heavy isotopes have been incorporated into drug molecules, primarily as tracers for quantitation during the drug development process. Deuteration has garnered attention due to its potential to influence the pharmacokinetic and metabolic profiles of drugs.
- Deuterium labeled compound
- Potent inhibitor of wild-type JAK2 and JAK2V617F mutant
- Inhibits FLT3 and its mutant FLT3D835Y
- Used as a tracer for quantitation during drug development
- Potential to affect pharmacokinetic and metabolic profiles
Medchemexpress LLC 1-bromoundecane-d4 | 1219802-82-0 | 98.8% | 5 MG
1-Bromoundecane-d4 is the deuterium-labeled analogue of 1-bromoundecane supplied as an isotope-labeled standard for analytical and research use.
- Isotope-labeled tracer and internal standard for analytical applications.
- CAS 1219802-82-0.
- Molecular formula C11H19D4Br.
- Molecular weight 239.23 Da.
- Purity 98.8% (as listed).
- Available in small pack sizes such as 5 mg.
Medchemexpress LLC P-Tolualdehyde-d7 | 1219805-23-8 | 98.2% | 127.19 | 10 MG
p-Tolualdehyde-d7 is the deuterium-labeled version of p-Tolualdehyde. p-Tolualdehyde is an active small molecule that can be used as a drug intermediate. This product is for research use only and not sold to patients.
- Can be used as a tracer.
- Can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
- Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, primarily as tracers for quantitation during the drug development process.
- Deuteration may affect the pharmacokinetic and metabolic profiles of drugs.
![Revvity Health Sciences Inc Cyclopentyl-1,3-Dipropylxanthine, 8-[Dipropyl-2,3-<sup>3</sup>H(N)]-, 1mCi (37MBq)](https://assets.fishersci.com/TFS-Assets/CCG/product-images/502811004.jpg-250.jpg)
Revvity Health Sciences Inc Cyclopentyl-1,3-Dipropylxanthine, 8-[Dipropyl-2,3-3H(N)]-, 1mCi (37MBq)
Cyclopentyl-1,3-Dipropylxanthine, 8-[Dipropyl-2,3-3H(N)]-, 1mCi (37MBq)
![Revvity Health Sciences Inc Oleic Acid, [9,10-<sup>3</sup>H(N)]-, 1mCi (37MBq)](https://assets.fishersci.com/TFS-Assets/CCG/product-images/502811076.jpg-250.jpg)
Revvity Health Sciences Inc Oleic Acid, [9,10-3H(N)]-, 1mCi (37MBq)
Oleic Acid, [9,10-3H(N)]-, 1mCi (37MBq)
![Revvity Health Sciences Inc Human growth hormone, [<sup>125</sup>I], 50 µCi](https://assets.fishersci.com/TFS-Assets/CCG/product-images/VN00001872-502097588.JPG-250.jpg)
Revvity Health Sciences Inc Human growth hormone, [125I], 50 µCi
Human growth hormone, [125I], 50 µCi
Medchemexpress LLC Perphenazine-d4 | 155593-75-2 | 98.8% | C21H22D4ClN3OS | 5 MG
Perphenazine-d4 is the deuterium labeled Perphenazine, a typical antipsychotic agent. It inhibits several receptors including 5-HT2A, Alpha-1A adrenergic, Dopamine D2/D3, D2L, and Histamine H1 receptors. Deuteration can affect the pharmacokinetic and metabolic profiles of drugs, making Perphenazine-d4 useful as a tracer for quantitation in drug development.
- Deuterium labeled Perphenazine
- Typical antipsychotic agent
- Inhibits 5-HT2A receptor, Alpha-1A adrenergic receptor, Dopamine receptor D2/D3, D2L receptor, and Histamine H1 receptor
- Useful as tracers for quantitation during drug development
- Relevant in studies related to 5-HT Receptor, Adrenergic Receptor, Apoptosis, Autophagy, Dopamine Receptor, and Histamine Receptor pathways
- Applicable in research involving GPCR/G Protein, Neuronal Signaling, Apoptosis, Autophagy, and Immunology/Inflammation pathways
Apexbio Technology LLC Deoxycholic acid 83-44-3 20mg
Deoxycholic acid (CAS 83-44-3) is a secondary bile acid derived from cholic acid commonly extracted from animal bile sources such as pig bile It acts as a natural surfactant involved in the emulsification and absorption of dietary fats in the intestine by disrupting lipid membranes and facilitating micelle formation Owing to its amphipathic properties deoxycholic acid is widely utilized in studies investigating lipid metabolism cell membrane dynamics and bile acid signaling pathways The compound is soluble in ethanol ether methanol acetone acetic acid and alkaline solutions and is typically stored in a sealed cool and dry environment to maintain stability
Medchemexpress LLC DL-Alanine-d3 | 53795-94-1 | 250 MG
This product is a deuterium-labeled form of DL-alanine, an amino acid that exists as a racemic mixture of its L- and D- forms. It acts as both a reducing and capping agent, particularly with silver nitrate aqueous solutions for nanoparticle production. Additionally, it is useful in the study of transition metal chelation, such as with copper (II), zinc (II), and cadmium (II). It is also recognized as a sweetener, alongside substances like glycine and sodium saccharin, and plays a significant role in the glucose-alanine cycle occurring between tissues and the liver.
- It can be used as a tracer.
- It can serve as an internal standard for quantitative analysis through techniques like NMR, GC-MS, or LC-MS.
- Stable heavy isotopes have been incorporated into drug molecules for quantitation during drug development.
- Deuteration may impact the pharmacokinetic and metabolic profiles of drugs.
Medchemexpress LLC L-Xylose-2-13C | 478506-63-7 | 99.0% | C₄¹³CH₁₀O₅ | 50 MG
L-Xylose-2-13C is a carbon-13 labeled form of L-Xylose, a rare and levorotatory sugar. This compound serves as a raw material for the synthesis of various drugs and bioactive molecules.
- Can be used as a tracer
- Can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS
Cambridge Isotope Laboratories AMMONIA (15N, 98%), 1 L, 13767-16-3
AMMONIA (15N, 98%), 1 L, 13767-16-3
Medchemexpress LLC Sarcosine-d3 (N-methylglycine-d3) | 118685-91-9 | MFCD01075434 | 99.1% | 92.11 g/mol | C3H4D3NO2 | 100 MG
Sarcosine-d3 (N-methylglycine-d3) is a deuterium-labeled analog of sarcosine supplied as a colorless to off-white solid for research use. It serves as a tracer and quantitative internal standard for NMR, GC-MS, and LC-MS analyses, and is commonly used in studies of glycine transport and NMDA receptor modulation (CAS 118685-91-9).
- Deuterium-labeled (d3) for accurate internal standardization.
- High chemical purity (≈99.1%).
- Water soluble (≈125 mg/mL); may require ultrasonic agitation.
- Stable as a powder at -20°C; in solution, store at -80°C for extended periods.
- Suitable as tracer and internal standard for NMR, GC-MS, and LC-MS quantitation.
![Revvity Health Sciences Inc Peptide YY (Human), ([<sup>125</sup>I]-PYY), 50µCi](https://assets.fishersci.com/TFS-Assets/CCG/product-images/VN00001872-502097654.JPG-250.jpg)
Revvity Health Sciences Inc Peptide YY (Human), ([125I]-PYY), 50µCi
Peptide YY (Human), ([125I]-PYY), 50µCi
Medchemexpress LLC Adamantane-d16 | 30470-60-1 | 25 MG
Adamantane-d16 is a deuterium-labeled polycyclic cage molecule known for its high symmetry and remarkable properties. It can be incorporated into the lipophilic part of lipid bilayers, serving as an anchor in liposomes. This compound is valuable in research for surface recognition and drug delivery studies. Deuteration of drug molecules, such as this, is also being studied for its potential to influence pharmacokinetic and metabolic profiles.
- Can be used as a tracer
- Can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS